Chloroform → 7-Chloro-2,3-dihydro-5-nitro-1H-indole

Participants

Reaction Steps

To a solution of 5-nitroindoline (0.5 g, 3.1 mmol) in 15 mL of AcOH was added a solution of Cl2 in AcOH dropwise until 30% of starting material was consumed. The reaction mixture was concentrated in vacuo, yielding an oil which was subjected to column chromatography (CHCl3, neat) to provide 0.23 g (1.2 mmol) of the desired product.

Provenance & Evidence