関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Stannous chloride dihydrate | HCID 61436 | — |
| 反応物 | 7-Bromo-5-nitrobenzothiazole | HCID 22728031 | — |
| 溶媒 | Hydrochloric Acid | HCID 313 | — |
| 生成物 | 7-Bromobenzo[d]thiazol-5-amine | HCID 22728037 | 9,687.5% |
反応手順
To a solution of SnCl2.2H2O (0.5 g, 2.2 mmol) in 5 mL of HCl was added 5-nitro-7-bromobenzothiazole (82 mg, 0.32 mmol) in a portion and the resulting reaction mixture was stirred for 1 h at 25° C. The reaction mixture was basified with aq. NaOH and extracted with EtOAc. Organic extracts were dried over Na2SO4 and concentrated in vacuo to yield 70 mg (31 mmol, 96%) of the desired product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06303643B1 |
|---|
| 出典データセット | uspto-grants-2001_10 |
|---|
| ORD ID | ord-e2709918f6d745339bb265065bc14af1 |
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| 出典メモ | uspto-grants-2001_10 |
|---|
