Tetramethyltin → 7-Methyl-5-nitro-1,3-benzothiazole

HRID 380618Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 380618
Br[C:2]1[C:10]2[S:9][CH:8]=[N:7][C:6]=2[CH:5]=[C:4]([N+:11]([O-:13])=[O:12])[CH:3]=1.[CH3:14][Sn](C)(C)C>CCOC(C)=O>[CH3:14][C:2]1[C:10]2[S:9][CH:8]=[N:7][C:6]=2[CH:5]=[C:4]([N+:11]([O-:13])=[O:12])[CH:3]=1

Komponenten

4

Edukt 2

HCID 11661TetramethyltinHCID 227280317-Bromo-5-nitrobenzothiazole

Produkt 1

HCID 227280277-Methyl-5-nitro-1,3-benzothiazoleAusbeute 67 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel2×

Versuchsvorschrift

A solution of 7-bromo-5-nitrobenzothiazole (0.15 g, 0.58 mmol), tetramethyltin (0.20 mL, 0.1.5 mmol) and catalytic amount of Cl2Pd(PPh3) 2 in a sealed tube was stirred for 12 h at 90° C. The reaction mixture was diluted with EtOAc and washed with brine several times. Organic solution was dried over Na2SO4 and concentrated in vacuo, yielding an oil which was subjected to column chromatography (EtOAc, neat) to provide 65 mg (0.32 mmol, 67%) of the desired product.

Aufarbeitung

  1. washwashed with brine several times
  2. dry with materialOrganic solution was dried over Na2SO4
  3. concentrationconcentrated in vacuo
  4. customyielding an oil which

Quellen und Nachweise

ORD-Eintrag
ord-265d6f99aaa1485fa47d0a41f2d970a2
Quelldatensatz
uspto-grants-2001_10
Patentnummer
US06303643B1

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