HCID 14302855, compound → HCID 57311524, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (2R)-5-t-butyldiphenylsiloxy-2-hydroxy-2-(hydroxymethyl)-1,2,3,4-tetrahydronaphthalene (0.49 g) and N,N-di(4-fluorophenyl)carbamoyl chloride (1.08 g) in pyridine (2.3 ml) was stirred at 100° C. for 1.5 hours. The reaction mixture was partitioned between ethyl acetate and water. The organic layer was washed with water, 1N-HCl, and evaporated in vacuo. The residue was purified by chromatography on silica gel (50 ml) using a mixture of AcOEt and n-hexane to give (2R)-5-t-butyldiphenylsiloxy-2-{[N,N-di(4-fluorophenyl)-carbamoyloxy]methyl}-2-hydroxy-1,2,3,4-tetrahydronaphthalene (0.356 g) as an oil.

Provenance & Evidence