Sodium Hydroxide → HCID 20695077, compound

Participants

Reaction Steps

To a solution of (2R)-5-[(ethoxycarbonyl)methoxy]-2-[(N-4-fluorophenyl-N-phenylcarbamoyloxy)methyl]-2-hydroxy-1,2,3,4-tetrahydronaphthalene (80 mg) in ethanol (5 ml) was added 1N-NaOH solution (0.2 ml). After being stirred for 4 hours at the same temperature, the solvent was removed in vacuo. The residue was washed with 1N-HCl solution and brine. The dried solvent was removed in vacuo to give (2R)-5-(carboxymethoxy)-2-[(N-4-fluorophenyl-N-phenyl-carbamoyloxy)methyl]-2-hydroxy-1,2,3,4-tetrahydronaphthalene (32 mg).

Provenance & Evidence