1,3,3-Trimethyl-2-methylene-5-nitroindoline → HCID 18365550, compound

HRID 380655Notes

Reaction equation

HRID 380655 reaction equation
[N:1]1([C:6]2[CH:11]=[CH:10][C:9]([C:12]3[C:21]4[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=4)[C:15](=[O:22])[C:14](=[N:23]O)[CH:13]=3)=[CH:8][CH:7]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:25][N:26]1[C:34]2[C:29](=[CH:30][C:31]([N+:35]([O-:37])=[O:36])=[CH:32][CH:33]=2)[C:28]([CH3:39])([CH3:38])[C:27]1=[CH2:40]>>[CH3:25][N:26]1[C:27]2([O:22][C:15]3[C:16]4[C:21]([C:12]([C:9]5[CH:8]=[CH:7][C:6]([N:1]6[CH2:2][CH2:3][CH2:4][CH2:5]6)=[CH:11][CH:10]=5)=[CH:13][C:14]=3[N:23]=[CH:40]2)=[CH:20][CH:19]=[CH:18][CH:17]=4)[C:28]([CH3:38])([CH3:39])[C:29]2[C:34]1=[CH:33][CH:32]=[C:31]([N+:35]([O-:37])=[O:36])[CH:30]=2

Participants

3

Reactant 2

HCID 1189711,3,3-Trimethyl-2-methylene-5-nitroindolineHCID 178516822HCID 178516822, compound

Product 1

HCID 18365550HCID 18365550, compound

Procedure

The method according to claim 9, wherein 4-(4-pyrrolidinophenyl)-1,2-naphthoquinone-2-oxime and 1,3,3-trimethyl-2-methylene-5-nitroindoline are reacted to form 1,3-Dihydro-1,3,3-trimethyl-5-nitro-6′-(4-pyrrolidinophenyl)spiro-[2H-indole-2,2′[2H]naphth[1,2-b][1,4]oxazine].

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-f8a699d40ba8484e92180af7371ceaa4
Source dataset
uspto-grants-2001_10
Patent number
US06303673B1

Reaction notes

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