Trifluoroacetic acid → 4-benzylpiperidine-4-carboxylic acid N',N'-dimethylhydrazide

Participants

Reaction Steps

To a solution of 4-benzyl-4-(N′,N′-dimethylhydrazinocarbonyl)piperidine-1-carboxylic acid tert-butyl ester (0.76 g, 2.02 mmol) in methylene chloride (2 ml) at 0° C. was added trifluoroacetic acid (5 ml) and the mixture was stirred for 60 min. The mixture was quenched with ethanol (20 ml), concentrated in vacuo and stripped three times with methylene chloride to give 4-benzylpiperidine-4-carboxylic acid N′,N′-dimethylhydrazide in quantitative yield.

Provenance & Evidence