Hydrochloric Acid → HCID 20670032, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of the amino compound from Example 54 (0.10 g), potassium carbonate (0.087 g) and N-(2-chloroethyl)dimethylamine hydrochloride was stirred and heated at 138° C. for 72 hr. The residue was dissolved in water and the product extracted into ethyl acetate. The organic extract was washed with brine, dried over sodium sulphate (Na2SO4) and concentrated to give an oil which was purified by Supercritical Fluid Chromatography eluting with CO2/methanol/0.1% diethylamine to give an oil. Addition of excess ethereal hydrogen chloride solution gave a solid which was triturated under an ether/ethanol/dichloromethane mixture to give a colourless powder (0.04 g).

Provenance & Evidence