4-Methoxyphenylacetic Acid → Manganese chloride (MnCl2), monohydrate

HRID 380706Notes

Reaction equation

HRID 380706 reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([OH:12])=[O:11])=[CH:5][CH:4]=1.C(=O)([O-])[O-].[Na+:17].[Na+].[Cl-:19].[Mn+2:20].[Cl-]>>[C:6]1([CH2:9][C:10]([O-:12])=[O:11])[CH:7]=[CH:8][CH:3]=[CH:4][CH:5]=1.[Na+:17].[OH2:2].[Cl-:19].[Cl-:19].[Mn+2:20]

Participants

5

Reactant 3

HCID 76904-Methoxyphenylacetic AcidHCID 10340Sodium CarbonateHCID 10313134Manganese(2+) dichloride

Product 2

HCID 18365734Manganese chloride (MnCl2), monohydrateHCID 23690424Sodium Phenylacetate

Procedure

Turning now to FIG. 1, a four step synthetic route for the preparation of α,δ-bis(4-hydroxy)sexiphenylene, in accordance with an embodiment of the present invention, is presented. Thus in a first step, a first solution is prepared by adding an appropriate amount of 4-methoxyphenylacetic acid to an aqueous solution of sodium carbonate. To this first solution is added an appropriate amount of a second solution, aqueous manganese chloride, to produce a pink foamy mixture. This mixture is washed with water and filtered to yield a pink powder, now comprising sodium phenylacetate and manganese dichloride hydrate. This pink powder is distilled at 300-320° C. under vacuum to effect a thermally induced dehydrative coupling reaction to give an excellent yield (72%) of white crystals of 1,3-bis(4-methoxyphenyl)propanone, having a melting point of between approximately 75-76° C.

Workup

  1. customa four step synthetic route for the preparation of α,δ-bis(4-hydroxy)sexiphenylene
  2. customThus in a first step, a first solution is prepared
  3. customto produce a pink foamy mixture
  4. washThis mixture is washed with water
  5. filtrationfiltered

Sources & evidence

ORD record
ord-7b8c29d8226e4f6fa6c9a7a36ee52048
Source dataset
uspto-grants-2001_10
Patent number
US06303733B1

Reaction notes

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