反应详情

1.46 g (5.5 mmol) of 3-(4-ethoxytetrahydrofuran-3-yloxy)-4-methoxybenzonitrile (A7) and 3.0 g (55.0 mmol) of potassium hydroxide are heated at 140° C. for 3 h in 15 ml of glycerol. The mixture is treated with 50 ml of water, washed with 2×25 ml of ethyl acetate and the aqueous phase is acidified by dropwise addition of 30 ml of 2 N hydrochloric acid with ice-cooling. The mixture is subsequently stirred for 1 h, filtered and the precipitate is washed with ice water. 1.49 g of the title compound of m.p. 135-138° C. are obtained.

1. washwashed with 2×25 ml of ethyl acetate
2. additionthe aqueous phase is acidified by dropwise addition of 30 ml of 2 N hydrochloric acid with ice-
3. temperaturecooling
4. filtrationfiltered
5. washthe precipitate is washed with ice water