HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 380761Generated: November 2, 2026
Water → N-Tert-butyl-6-morpholin-4-YL-4-O-tolyl-nicotinamide
https://huagongshe.com/reaction/380761
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | N-(tert-butyl)-6-chloro-4-(o-tolyl)nicotinamide | HCID 12167313 | — |
| Solvent | Sodium chloride; water | HCID 57417360 | — |
| Product | N-Tert-butyl-6-morpholin-4-YL-4-O-tolyl-nicotinamide | HCID 12167315 | 93.8% |
Reaction Steps
A mixture of 6.0 g (19 mMol) of N-tert.-butyl-6-chloro-4-o-tolyl-nicotinamide and 12 ml (138 mMol) morpholine was heated at 100° C. for 4 hours. After cooling to room temperature, extractive work-up with ethyl acetate, water and brine yielded 6.3 g (91%) of N-tert.-butyl-6-morpholin-4-yl-4-o-tolyl-nicotinamide as a brown crystalline foam.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06303790B1 |
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| Source dataset | uspto-grants-2001_10 |
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| ORD ID | ord-e5601c99f6d74e40b865495cbf5aecd5 |
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| Source note | uspto-grants-2001_10 |
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