HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-butyl (2S)-2-formylpyrrolidine-1-carboxylate → (S)-N-Boc-2-ethynylpyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-butyl (2S)-2-formylpyrrolidine-1-carboxylate | HCID 2734674 | — |
| Reactant | Diazomethyl-phosphonic-acid-diethylester | HCID 10943016 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | (S)-N-Boc-2-ethynylpyrrolidine | HCID 11030701 | — |
Reaction Steps
(S)-N-Boc-2-Ethynyl-pyrrolidine was prepared according to Method X above by the treatment of (S)-N-Boc-2-formyl-pyrrolidine (470 mg, 2.36 mmol) (Example 87A above) with potassium tert-butoxide (340 mg, 3.07 mmol) and diazomethyl-phosphonic-acid-diethylester (550 mg, 3.07 mmol) (also prepared according to Method X). The product was obtained after silica gel column chromatography with 10% Et2O in hexanes. (Yield 200 mg, 43%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06303793B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-80de765d0664493da5b5d1bcd9c381ed |
| Source note | uspto-grants-2001_10 |