化工社化工社 化学情報印刷レポート · 研究参考用
Iodoethane → Methyl 2-(4-t-butylphenyl)butanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Iodoethane | HCID 6340 | — |
| 反応物 | Methyl p-tert-butylphenylacetate | HCID 605629 | — |
| 反応物 | Lithium Hexamethyldisilazide | HCID 2733832 | — |
| 生成物 | Methyl 2-(4-t-butylphenyl)butanoate | HCID 10728413 | 115.2% |
反応手順
4 g (19 mmol) of methyl 4-tert-butylphenylacetate, 19.5 mL (1.0 M, 19 mmol) of lithium bis(trimethylsilyl)amide and 3.12 g (20 mmol) of ethyl iodide were reacted as described in Preparation 11 to yield 5.13 g of a brown oil. Chromatography, eluting with a gradient solvent of hexane to hexane/ethyl acetate 19:1 gave the title compound 2.35 g (53%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06303816B1 |
| 出典データセット | uspto-grants-2001_10 |
| ORD ID | ord-666de0979c4f478fb2fab98834d013a3 |
| 出典メモ | uspto-grants-2001_10 |