Sodium Cyanide → HCID 73447331, compound

HRID 381220Notes

Reaction equation

HRID 381220 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4]([Cl:12])[C:3]=1[NH:13][N:14]=[C:15](Cl)[C:16]1[CH:23]=[CH:22][C:19]([C:20]#[N:21])=[CH:18][CH:17]=1.[C-:25]#[N:26].[Na+]>O.C(O)C>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4]([Cl:12])[C:3]=1[NH:13][N:14]=[C:15]([C:16]1[CH:23]=[CH:22][C:19]([C:20]#[N:21])=[CH:18][CH:17]=1)[C:25]#[N:26]

Participants

5

Reactant 2

HCID 8929Sodium CyanideHCID 73447334HCID 73447334, compound

Product 1

HCID 73447331HCID 73447331, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolvent2×HCID 962WaterSolvent3×

Procedure

55 g of solid 4-{1-[(2,6-dichloro-4-trifluoromethylphenyl)hydrazono]chloromethyl}benzonitrile are added in portions in the course of approximately one hour to 11.4 g of sodium cyanide in 270 ml of water and 400 ml of ethanol. After the mixture has been stirred for three hours at room temperature, 200 ml of ethanol and 135 ml of water are added and the mixture is stirred for a further 5 hours. 100 ml of water are added slowly, the precipitate is filtered off and washed with water, and the filter residue is dried in vacuo at 40°. This gives the title compound of melting point 186-187° (compound no. 3.4).

Workup

  1. stirringthe mixture is stirred for a further 5 hours
  2. filtrationthe precipitate is filtered off
  3. washwashed with water
  4. customthe filter residue is dried in vacuo at 40°

Sources & evidence

ORD record
ord-5d2ff8fddacd41a2886b51098e8d318c
Source dataset
uspto-grants-2001_10
Patent number
US06306798B1

Reaction notes

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