HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 381287Generated: October 31, 2026
Potassium Carbonate → 7-Oxo-5-phenyl-N-{3-[4-[2-(2,2,2-trifluoroethoxy)phenyl]-1-piperazinyl]propyl}-7H-thieno[3,2-b]pyran-3-carboxamide
https://huagongshe.com/reaction/381287
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-[2-(2,2,2-Trifluoroethoxy)phenyl]piperazine | HCID 10491565 | — |
| Reactant | N-(3-Chloropropyl)-7-oxo-5-phenyl-7H-thieno[3,2-b]pyran-3-carboxamide | HCID 22464456 | — |
| Product | 7-Oxo-5-phenyl-N-{3-[4-[2-(2,2,2-trifluoroethoxy)phenyl]-1-piperazinyl]propyl}-7H-thieno[3,2-b]pyran-3-carboxamide | HCID 9937984 | 70% |
Reaction Steps
A mixture of 0.17 g of Compound 5A, 0.13 g of 1-[2-(2,2,2-trifluoroethoxy)phenyl]-piperazine (prepared as described by EP 0748 800, G. Bantle et al.) and 0.07 g of potassium carbonate was heated at 200° C. for 20 minutes. After cooling to 20-25° C., the crude residue was purified by flash chromatography in ethyl acetate/methanol gradient (95:5 to 9:1) to yield 0.193 g (70%) of the title compound. M.p. 152-158° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06306861B1 |
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| Source dataset | uspto-grants-2001_10 |
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| ORD ID | ord-98f8e943100e4ab9a3087b38e421c7be |
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| Source note | uspto-grants-2001_10 |
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