HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 5-Chlorothiophene-2-carbonyl Chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 5-Chloro-2-thiophenecarboxylic acid | HCID 95048 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 5-Chlorothiophene-2-carbonyl Chloride | HCID 589223 | — |
Reaction Steps
To a chilled solution of 5-chlorothiophene-2-carboxylic acid (0.16 g, 1.0 mmol) in EtOAc (3 mL) and DMF (1 drop) was added neat oxalyl chloride (92 μL, 1.05 mmol). The reaction mixture was stirred cold for 2 hr and concentrated in vacuo to give crude 5-chlorothiophene-2-carbonyl chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08524721B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-f3ab523db84d4747a39bf21f2f7e9033 |
| Source note | uspto-grants-2013_09 |