Hydrochloric Acid → 6-[1-(3-Nitro-2-pyridyl)piperazin-4-yl-carbonyl]nicotinic acid

Participants

Reaction Conditions

Reaction Steps

6-[1-(3-Nitro-2-pyridyl)piperazin-4-yl-carbonyl]nicotinic acid methyl ester (10 g) was dissolved in methanol (75 ml) and with the addition of aqueous 1N-sodium hydroxide (75 ml), the mixture was stirred at 30° C for 2 hours. With the slow addition of 3N-hydrochloric acid for neutralization (pH=˜5), water (110 ml) was slowly added to the mixture for precipitate. After 2-hours stirring, the precipitate was filtered, washed with water and dried to give a desired compound of 8.66 g (yield: 90%).

Provenance & Evidence