HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-1-butanol, (-)- → 5-[N-[(1R)-1-ethyl-2-hydroxyethyl]carbamoyl]-2-[1-[3-(isopropylamino)-2-pyridyl]piperazin-4-yl-carbonyl]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-1-butanol, (-)- | HCID 2723856 | — |
| Reactant | 6-[1-[3-(Isopropylamino)-2-pyridyl]piperazin-4-yl-carbonyl]nicotinic acid | HCID 18362818 | — |
| Product | 5-[N-[(1R)-1-ethyl-2-hydroxyethyl]carbamoyl]-2-[1-[3-(isopropylamino)-2-pyridyl]piperazin-4-yl-carbonyl]pyridine | HCID 9932943 | 83% |
Reaction Steps
By the same procedure as described in the example 1, synthesis was carried out starting with 6-[1-[3-(isopropylamino)-2-pyridyl]piperazin-4-yl-carbonyl]nicotinic acid and using (R)-(−)-2-amino-1-butanol. Then, the product was recrystallized with ethanol and petroleum ether to give a desired compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06306860B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-a442db1eda524530a9dbcc660cf82b87 |
| Source note | uspto-grants-2001_10 |