Serinol → 5-[N-[Bis(hydroxymethyl)methyl]carbamoyl]-2-[1-[3-(isopropylamino)-2-pyridyl]piperazin-4-yl-carbonyl]pyridine

Participants

Role	Name	HCID	Charge
Reactant	Serinol	HCID 68294	—
Reactant	6-[1-[3-(Isopropylamino)-2-pyridyl]piperazin-4-yl-carbonyl]nicotinic acid methyl ester	HCID 10937848	—
Product	5-[N-[Bis(hydroxymethyl)methyl]carbamoyl]-2-[1-[3-(isopropylamino)-2-pyridyl]piperazin-4-yl-carbonyl]pyridine	HCID 9824625	78%

Reaction Steps

By the same procedure as described in the example 2, synthesis was carried out starting with 6-[1-[3-(isopropylamino)-2-pyridyl]piperazin-4-yl-carbonyl]nicotinic acid methyl ester and using 2-amino-1,3-propandiol. Then, the product was recrystallized with ethyl acetate and hexane to give a desired compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06306860B1
Source dataset	uspto-grants-2001_10
ORD ID	ord-7b102423714244ad949f44964a3315f7
Source note	uspto-grants-2001_10