2-(Ethylamino)ethanol → 5-[N-ethyl-N-(2-hydroxyethyl)carbamoyl]-2-[1-[3-(isopropylamino)-2-pyridyl]piperazin-4-yl-carbonyl]pyridine

Participants

Role	Name	HCID	Charge
Reactant	2-(Ethylamino)ethanol	HCID 8072	—
Reactant	6-[1-[3-(Isopropylamino)-2-pyridyl]piperazin-4-yl-carbonyl]nicotinic acid	HCID 18362818	—
Product	5-[N-ethyl-N-(2-hydroxyethyl)carbamoyl]-2-[1-[3-(isopropylamino)-2-pyridyl]piperazin-4-yl-carbonyl]pyridine	HCID 18362850	74%

Reaction Steps

By the same procedure as described in the example 1, synthesis was carried out starting with 6-[1-[3-(isopropylamino)-2-pyridyl]piperazin-4-yl-carbonyl]nicotinic acid and using 2-(ethylamino)ethanol. And then, the product was recrystallized with isopropanol and hexane to give a desired compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06306860B1
Source dataset	uspto-grants-2001_10
ORD ID	ord-ab7586601af846aa8d820bd907c1425a
Source note	uspto-grants-2001_10