Isobutylamine → 2-[1-[3-(ethylamino)-2-pyridyl]piperazin-4-yl-carbonyl]-5-[N-(2-methylpropyl)carbamoyl]pyridine

HRID 381367Notes

Reaction equation

HRID 381367 reaction equation
[CH2:1]([NH:3][C:4]1[C:5]([N:10]2[CH2:15][CH2:14][N:13]([C:16]([C:18]3[CH:26]=[CH:25][C:21]([C:22]([OH:24])=O)=[CH:20][N:19]=3)=[O:17])[CH2:12][CH2:11]2)=[N:6][CH:7]=[CH:8][CH:9]=1)[CH3:2].[CH2:27]([NH2:31])[CH:28]([CH3:30])[CH3:29]>>[CH2:1]([NH:3][C:4]1[C:5]([N:10]2[CH2:15][CH2:14][N:13]([C:16]([C:18]3[CH:26]=[CH:25][C:21]([C:22](=[O:24])[NH:31][CH2:27][CH:28]([CH3:30])[CH3:29])=[CH:20][N:19]=3)=[O:17])[CH2:12][CH2:11]2)=[N:6][CH:7]=[CH:8][CH:9]=1)[CH3:2]

Participants

3

Reactant 2

HCID 6558IsobutylamineHCID 18362847HCID 18362847, compound

Product 1

HCID 183628122-[1-[3-(ethylamino)-2-pyridyl]piperazin-4-yl-carbonyl]-5-[N-(2-methylpropyl)carbamoyl]pyridineYield 77%

Procedure

By the same procedure as described example 24, the synthesis was carried out starting with 6-[1-[3-(ethylamino)-2-pyridyl]piperazin-4-yl-carbonyl]nicotinic acid and using isobutylamine. And then, the product was recrystallized with ethanol and hexane to give a desired compound.

Workup

  1. customAnd then, the product was recrystallized with ethanol and hexane

Sources & evidence

ORD record
ord-4407b7a1c6434ccbb0b80af651550a62
Source dataset
uspto-grants-2001_10
Patent number
US06306860B1

Reaction notes

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