Diisopropylamine → HCID 18362819, compound

HRID 381369Notes

Reaction equation

[CH2:1]([NH:3][C:4]1[C:5]([N:10]2[CH2:15][CH2:14][N:13]([C:16]([C:18]3[CH:26]=[CH:25][C:21]([C:22](O)=[O:23])=[CH:20][N:19]=3)=[O:17])[CH2:12][CH2:11]2)=[N:6][CH:7]=[CH:8][CH:9]=1)[CH3:2].[CH:27]([NH:30][CH:31]([CH3:33])[CH3:32])([CH3:29])[CH3:28]>>[CH:27]([N:30]([CH:31]([CH3:33])[CH3:32])[C:22]([C:21]1[CH:25]=[CH:26][C:18]([C:16]([N:13]2[CH2:12][CH2:11][N:10]([C:5]3[C:4]([NH:3][CH2:1][CH3:2])=[CH:9][CH:8]=[CH:7][N:6]=3)[CH2:15][CH2:14]2)=[O:17])=[N:19][CH:20]=1)=[O:23])([CH3:29])[CH3:28]

Participants

Reactant 2

HCID 7912Diisopropylamine

HCID 18362847HCID 18362847, compound

Product 1

HCID 18362819HCID 18362819, compoundYield 72%

Procedure

By the same procedure as described in the example 24, the synthesis was carried out starting with 6-[1-[3-(ethylamino)-2-pyridyl]piperazin-4-yl-carbonyl]nicotinic acid and using diisopropylamine. And then, the product was recrystallized with acetone and hexane to give a desired compound.

Workup

customAnd then, the product was recrystallized with acetone and hexane

Sources & evidence

ORD record: ord-b974a522e0ba441181bb978d9bf96b9a
Source dataset: uspto-grants-2001_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06306860B1

Reaction notes

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