HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopropylamine → 5-(N-cyclopropylcarbamoyl)-2-[1-[3-(isopropylamino)-2-pyridyl]piperazin-4-yl-carbonyl]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopropylamine | HCID 69828 | — |
| Reactant | 6-[1-[3-(Isopropylamino)-2-pyridyl]piperazin-4-yl-carbonyl]nicotinic acid methyl ester | HCID 10937848 | — |
| Product | 5-(N-cyclopropylcarbamoyl)-2-[1-[3-(isopropylamino)-2-pyridyl]piperazin-4-yl-carbonyl]pyridine | HCID 499745 | 77% |
Reaction Steps
By the same procedure as described in the example 25, the synthesis was carried out starting with 6-[1-[3-(isopropylamino)-2-pyridyl]piperazin-4-yl-carbonyl]nicotinic acid methyl ester and using cyclopropylamine. And then, the product was recrystallized with isopropanol and petroleum ether to give a desired compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06306860B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-93de11d54c514931b1f0847abbf7620c |
| Source note | uspto-grants-2001_10 |