Diglycolamine → 5-[N-[2-(2-hydroxyethoxy)ethyl]carbamoyl]-2-[1-[3-(isopropylamino)-2-pyridyl]piperazin-4-yl-carbonyl]pyridine

Participants

Role	Name	HCID	Charge
Reactant	Diglycolamine	HCID 13578	—
Reactant	6-[1-[3-(Isopropylamino)-2-pyridyl]piperazin-4-yl-carbonyl]nicotinic acid methyl ester	HCID 10937848	—
Product	5-[N-[2-(2-hydroxyethoxy)ethyl]carbamoyl]-2-[1-[3-(isopropylamino)-2-pyridyl]piperazin-4-yl-carbonyl]pyridine	HCID 9846871	79%

Reaction Steps

By the same procedure as described in the example 25, the synthesis was carried out starting with 6-[1-[3-(isopropylamino)-2-pyridyl]piperazin-4-yl-carbonyl]nicotinic acid methyl ester and using 2-(2-aminoethoxy)ethanol. And then, the product was recrystallized with acetone and hexane to give a desired compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06306860B1
Source dataset	uspto-grants-2001_10
ORD ID	ord-2594a3c3604d459894fb4545c531e336
Source note	uspto-grants-2001_10