HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Pyridinemethanamine → 6-[1-[3-(ethylamino)-2-pyridyl]piperazin-4-yl-carbonyl]-N-(2-pyridylmethyl)nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Pyridinemethanamine | HCID 19509 | — |
| Reactant | HCID 18362847 | HCID 18362847 | — |
| Product | 6-[1-[3-(ethylamino)-2-pyridyl]piperazin-4-yl-carbonyl]-N-(2-pyridylmethyl)nicotinamide | HCID 499738 | 70% |
Reaction Steps
By the same procedure as described in the example 73, synthesis was carried out starting with 6-[1-[3-(ethylamino)-2-pyridyl]piperazin-4-yl-carbonyl]nicotinic acid and using 2-(aminomethyl)pyridine. And then, the product was chromatographed on column (hexane/methylene chloride/ethyl acetate=2/1/1, v/v/v) and crystallized with ether to give a desired compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06306860B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-3c7f76d906b64731893deedb2b5b00e8 |
| Source note | uspto-grants-2001_10 |