1H-Imidazole-1-propanamine → HCID 499764, compound

HRID 381384Notes

Reaction equation

HRID 381384 reaction equation
[CH2:1]([NH:5][C:6]1[C:7]([N:12]2[CH2:17][CH2:16][N:15]([C:18]([C:20]3[CH:28]=[CH:27][C:23]([C:24]([OH:26])=O)=[CH:22][N:21]=3)=[O:19])[CH2:14][CH2:13]2)=[N:8][CH:9]=[CH:10][CH:11]=1)[CH:2]([CH3:4])[CH3:3].[NH2:29][CH2:30][CH2:31][CH2:32][N:33]1[CH:37]=[CH:36][N:35]=[CH:34]1>>[N:33]1([CH2:32][CH2:31][CH2:30][NH:29][C:24](=[O:26])[C:23]2[CH:27]=[CH:28][C:20]([C:18]([N:15]3[CH2:16][CH2:17][N:12]([C:7]4[C:6]([NH:5][CH2:1][CH:2]([CH3:3])[CH3:4])=[CH:11][CH:10]=[CH:9][N:8]=4)[CH2:13][CH2:14]3)=[O:19])=[N:21][CH:22]=2)[CH:37]=[CH:36][N:35]=[CH:34]1

Participants

3

Reactant 2

HCID 787361H-Imidazole-1-propanamineHCID 18362800HCID 18362800, compound

Product 1

HCID 499764HCID 499764, compoundYield 66%

Procedure

By the same procedure as described in the example 81, synthesis was carried out starting with 6-[1-[3-(isobutylamino)-2-pyridyl]piperazin-4-yl-carbonyl]nicotinic acid and using 1-(3-aminopropyl)imidazole. And then, the product was recrystallized with isopropanol to give a desired compound.

Workup

  1. customBy the same procedure as described in the example 81, synthesis
  2. customAnd then, the product was recrystallized with isopropanol

Sources & evidence

ORD record
ord-0ea8d83e14cc4ecd8cc0fb3f8c31be21
Source dataset
uspto-grants-2001_10
Patent number
US06306860B1

Reaction notes

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