HCID 20696425, compound → HCID 18362848, compound

Participants

Reaction Steps

6-[1-(2-hydroxyethyl)piperazin-4-yl-carbonyl]nicotinic acid methyl ester (2 g) was dissolved in methanol (20 ml) and with the addition of ethanolamine (2 ml), the mixture was heated to reflux for 8 hours and concentrated under reduced pressure. The concentrated residue was dissolved in isopropanol (14 ml), and with the addition of isopropyl ether to precipitate. After 2-hours stirring, the filtered solid was recrystallized with ethyl acetate and hexane to give a desired compound of 1.74 g (yield: 79%).

Provenance & Evidence