4-Bromobenzyl bromide → HCID 69381349, compound

HRID 381402Notes

Reaction equation

HRID 381402 reaction equation
[Cl:1][C:2]1[CH:21]=[CH:20][C:5]([C:6]([N:8]2[C:16]3[C:11](=[CH:12][C:13]([O:17][CH3:18])=[CH:14][CH:15]=3)[CH:10]=[C:9]2[CH3:19])=O)=[CH:4][CH:3]=1.[CH2:22]([C:24]1[CH:25]=[C:26]([CH:30]=[CH:31][C:32]=1[Cl:33])[C:27]([NH2:29])=[O:28])[CH3:23].BrC1C=CC(CBr)=CC=1>>[Cl:1][C:2]1[CH:21]=[CH:20][C:5]([CH2:6][N:8]2[C:16]3[C:11](=[CH:12][C:13]([O:17][CH3:18])=[CH:14][CH:15]=3)[CH:10]=[C:9]2[CH3:19])=[CH:4][CH:3]=1.[CH2:22]([C:24]1[CH:25]=[C:26]([CH:30]=[CH:31][C:32]=1[Cl:33])[C:27]([NH2:29])=[O:28])[CH3:23]

Participants

3

Reactant 2

HCID 685274-Bromobenzyl bromideHCID 69379171HCID 69379171, compound

Product 1

HCID 69381349HCID 69381349, compound

Procedure

The procedure employed for preparation of Compound 9e was repeated except as follows. In the treatment of Compound 8e, 4-bromobenzyl bromide for N-alkylation was used instead of 4-CBC for N-acylation, so the resultant was 9h instead of 9e.

Sources & evidence

ORD record
ord-77a8ff05efc3460d9b233b75380720e9
Source dataset
uspto-grants-2001_10
Patent number
US06306890B1

Reaction notes

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