HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2R,3R)-2-(2,4-difluorophenyl)-3-[[1-(hydroxymethyl)-2-hydroxyethyl]-thio]-1-(1H-1,2,4-triazol-1-yl)-2-butanol → HCID 178462413, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2R,3R)-2-(2,4-difluorophenyl)-3-[[1-(hydroxymethyl)-2-hydroxyethyl]-thio]-1-(1H-1,2,4-triazol-1-yl)-2-butanol | HCID 10594623 | — |
| Reactant | 3-(4-Methanesulfonylphenyl)prop-2-enal | HCID 10750940 | — |
| Product | HCID 178462413 | HCID 178462413 | 58% |
Reaction Steps
Reaction and treatment were carried out in the same manner as in Example 4 using (2R,3R)-2-[2,4-difluorophenyl)-3-[(1,3-dihydroxy-2-propyl)thio]-1-(1H-1,2,4-triazol-1-yl)-2-butanol and trans-4-(methylsulfonyl)cinnamaldehyde to obtain the title compound, a major product as an oil in a yield of 58%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06306880B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-12e7250e429a4c14b7ffe19d2d974061 |
| Source note | uspto-grants-2001_10 |