HRID381410

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11171628

未命名化合物

结构：CC(C)(SC(CO)CO)C(O)(Cn1cncn1)c1ccc(C(F)(F)F)cc1

HCID18363280

未命名化合物

PRODUCTS

生成物

结构：CC(C)(S[C@H]1CO[C@H](/C=C/c2ccc(C(F)(F)F)cc2)OC1)C(O)(Cn1cncn1)c1ccc(C(F)(F)F)cc1

HCID178460847

未命名化合物

PROCEDURE

实验过程

Reaction was carried out in the same manner as in Example 4 using (RS)-3-[(1,3-dihydroxy-2-propyl)thio]-3-methyl-2-[4-(trifluoromethyl)phenyl]-1-(1H-1,2,4-triazol-1-yl)-2-butanol as described in Reference example 55 and trans-4-(trifluoromethyl)cinnamaldehyde as described in Reference example 22 to obtain the title compound as a colorless foam.

WORKUP

后处理

customReaction

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-efb64c06e8d049e2a0545b28ccc659a8
来源数据集: uspto-grants-2001_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06306880B1
来源说明: uspto-grants-2001_10

反应 SMILES

[OH:1][CH2:2][CH:3]([S:6][C:7]([CH3:27])([CH3:26])[C:8]([C:16]1[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][CH:17]=1)([OH:15])[CH2:9][N:10]1[CH:14]=[N:13][CH:12]=[N:11]1)[CH2:4][OH:5].[F:28][C:29]([F:41])([F:40])[C:30]1[CH:39]=[CH:38][C:33](/[CH:34]=[CH:35]/[CH:36]=O)=[CH:32][CH:31]=1>>[CH3:26][C:7]([S:6][C@@H:3]1[CH2:4][O:5][C@@H:36](/[CH:35]=[CH:34]/[C:33]2[CH:38]=[CH:39][C:30]([C:29]([F:28])([F:40])[F:41])=[CH:31][CH:32]=2)[O:1][CH2:2]1)([CH3:27])[C:8]([C:16]1[CH:17]=[CH:18][C:19]([C:22]([F:24])([F:23])[F:25])=[CH:20][CH:21]=1)([OH:15])[CH2:9][N:10]1[CH:14]=[N:13][CH:12]=[N:11]1