HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phthalic Anhydride → [4-(1,3-Dioxobenzo[c]azolidin-2-yl)phenyl]-n-[(5-chloro(2-thienyl))sulfonyl]carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phthalic Anhydride | HCID 6811 | — |
| Reactant | (4-Aminophenyl)-n-[(5-chloro(2-thienyl))sulfonyl]carboxamide | HCID 131724995 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | [4-(1,3-Dioxobenzo[c]azolidin-2-yl)phenyl]-n-[(5-chloro(2-thienyl))sulfonyl]carboxamide | HCID 20800262 | 55% |
Reaction Conditions
| Temperature | 110 °C |
|---|
Reaction Steps
A 22 mg portion (0.070) of (4-aminophenyl)-N-[(5-chloro(2-thienyl))sulfonyl]carboxamide was combined with 15 mg (0.10 mmol) of phthalic anhydride in 140 μL of DMF. After 18 h of heating at 110° C., the mixture was cooled and purified by RP-HPLC, to give 20 mg (55%) of the desired compound. ES-MS (M+H)+=447 (Cl).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08524721B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-82931409d5b34efca46b5addf10ed463 |
| Source note | uspto-grants-2013_09 |