[6-(2,2,3,3-Tetrafluoropropoxy)pyridin-3-yl]methanol → 6-(2,2,3,3-Tetrafluoropropoxy)nicotinaldehyde

HRID 381440Notes

Reaction equation

HRID 381440 reaction equation
[F:1][C:2]([F:16])([CH:13]([F:15])[F:14])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][OH:12])=[CH:7][N:6]=1>[O-2].[O-2].[Mn+4]>[F:16][C:2]([F:1])([CH:13]([F:15])[F:14])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([CH:11]=[O:12])=[CH:7][N:6]=1

Participants

3

Reactant 1

HCID 18363303[6-(2,2,3,3-Tetrafluoropropoxy)pyridin-3-yl]methanol

Product 1

HCID 105859326-(2,2,3,3-Tetrafluoropropoxy)nicotinaldehydeYield 96%

Reagents, catalysts & solvents 1

HCID 178418406HCID 178418406, compoundCatalyst

Procedure

2-(2,2,3,3-Tetrafluoropropoxy)-5-(hydroxymethyl)pyridine was treated with active manganese dioxide in the same manner as in Reference example 22 to obtain the title compound as an oil in a yield of 96%.

Sources & evidence

ORD record
ord-65bb2ba59e734b95b1ee63b78ecb92c1
Source dataset
uspto-grants-2001_10
Patent number
US06306880B1

Reaction notes

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