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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 381473Generated: October 26, 2026

Tryptamine → 1-Indan-5-yl-2,3,4,9-tetrahydro-1H-beta-carboline

https://huagongshe.com/reaction/381473

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTryptamineHCID 1150—
ReactantTrifluoroacetic acidHCID 6422—
Reactant5-IndanecarboxaldehydeHCID 121624—
Product1-Indan-5-yl-2,3,4,9-tetrahydro-1H-beta-carbolineHCID 1088073915.6%

Reaction Steps

This product was prepared using the same procedure as for Intermediate 1 with tryptamine (1.28 g, 8.0 mmol), indan-5-carboxaldehyde (1.3 g, 1.1 equiv.) and TFA (1.2 mL, 2 equiv.) to give the title compound (0.36 g, 14%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06306870B1
Source datasetuspto-grants-2001_10
ORD IDord-407958afdb2346f3baf4dbeda805a3ed
Source noteuspto-grants-2001_10