反应详情

温度

100 °C

A stirred solution of (E)-3-(4-aminophenyl)acrylic acid (1.0 g, 5.0 mmol) and potassium isocyanate (2.0 g, 5 equiv.) in a mixture of water and acetic acid (50 mL) was heated at 100° C. for 12 hours. After cooling, a white solid precipitated out. Filtration, washing of the filter cake with a mixture of water and MeOH, and drying it in vacuo gave the title compound (0.82 g, 80%) as a white solid.

1. temperatureAfter cooling
2. customa white solid precipitated out
3. filtrationFiltration
4. washwashing of the filter cake with a mixture of water and MeOH
5. customdrying it in vacuo