Sodium Hydroxide → HCID 70106174, compound

HRID 381485Notes

Reaction equation

HRID 381485 reaction equation
[C:1]([Si:5]([CH3:26])([CH3:25])[O:6][CH:7]([CH2:21][N:22]([CH3:24])[CH3:23])[CH2:8][C:9]1[CH:14]=[CH:13][C:12](/[CH:15]=[CH:16]/[C:17]([O:19]C)=[O:18])=[CH:11][CH:10]=1)([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+]>CO>[C:1]([Si:5]([CH3:25])([CH3:26])[O:6][C:7]([CH2:21][N:22]([CH3:24])[CH3:23])=[CH:8][C:9]1[CH:10]=[CH:11][C:12](/[CH:15]=[CH:16]/[C:17]([OH:19])=[O:18])=[CH:13][CH:14]=1)([CH3:2])([CH3:3])[CH3:4]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86755830HCID 86755830, compound

Product 1

HCID 70106174HCID 70106174, compoundYield 60%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

This product was prepared by refluxing for four hours (E)-3-[4-(2-(tertbutyldimethylsilanyloxy)-3-dimethylaminopropanyl)phenyl]acrylic acid, methyl ester (0.8 g, 2.03 mmol) and NaOH (1N) (4 mL, 2 equiv.) in 10 mL of MeOH. Evaporation of the solvent in vacuo and treatment with 5 mL of HCl (1 N) gave the title compound (0.4 g, 60%) as a beige solid solid.

Workup

  1. customThis product was prepared
  2. customEvaporation of the solvent in vacuo and treatment with 5 mL of HCl (1 N)

Sources & evidence

ORD record
ord-2d723b717bc9403f9c9333b62ead8a71
Source dataset
uspto-grants-2001_10
Patent number
US06306870B1

Reaction notes

Loading…