Potassium Carbonate → HCID 9957955, compound

Participants

Reaction Steps

To a solution of Example 58 (0.25 g, 0.57 mmol) in 50 mL of DMF was added K2CO3 (0.24 g, 3 equiv.) and an excess of dimethylaminodiethyl chloride (about 15 equiv.). The resulting mixture was heated at 60° C. for four hours until disappearance of the Jstarting material (tlc monitoring, DCM:MeOH (90:10). A new compound was formed (Rf=0.20). After evaporation of DMF, the residue was taken up in 150 mL of DCM, washed with 2×50 mL of water, dried over Na2SO4 and recrystallized from EtOH:H2O to give the title compound (0.06 g, 22%) as yellow crystals.

Provenance & Evidence