HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 131721986, compound → HCID 70107440, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 131721986 | HCID 131721986 | — |
| Catalyst | Zinc bromide | HCID 10421208 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 70107440 | HCID 70107440 | 98% |
Reaction Steps
A solution of Example 190 (0.33 g, 0.55 mmol) in DCM (30 mL) was treated with zinc bromide (0.63 g, 5 equiv.) for 16 hours at 30° C. A gummy solid was formed. Extraction with DCM:MeOH, washing with water, drying over Na2SO4 and recrystallization from iPrOH gave the title compound as white crystals in a 98% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06306870B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-717643529b994072ad4064d7ae76983e |
| Source note | uspto-grants-2001_10 |