Sodium Hydroxide → HCID 18363463, compound

Participants

Reaction Steps

In a similar manner to AI-3-1, 4-[3-methyl-1-(3-chlorobenzyl)-1H-pyrazol-4-yl]-2,4-dioxobutyric acid ethyl ester (crude from above) was reacted with 5 ml 1N NaOH in 20 ml methanol for two hours to give the title compound as a light tan solid. MP=183-184° C. 1H NMR (400 MHz, CDCl3) δ 2.54 (s, 3H), 5.23 (s, 2H), 6.67 (s, 1H), 7.12-7.18 (m, 1H), 7.25 (s, 1H), 7.31-7.36 (m, 2H), 7.97 (2, 1H).

Provenance & Evidence