Chlorosulfonic acid → HCID 135838097, compound

HRID 381566Notes

Reaction equation

HRID 381566 reaction equation
[Cl:1][S:2]([OH:5])(=O)=[O:3].[NH2:6][C:7]1[NH:16][C:15](=[O:17])[C:14]2[C:13]3[CH:18]=[CH:19][CH:20]=[CH:21][C:12]=3[CH2:11][CH2:10][C:9]=2[N:8]=1>>[NH2:6][C:7]1[NH:16][C:15](=[O:17])[C:14]2[C:13]3[CH:18]=[CH:19][C:20]([S:2]([Cl:1])(=[O:5])=[O:3])=[CH:21][C:12]=3[CH2:11][CH2:10][C:9]=2[N:8]=1

Participants

3

Reactant 2

HCID 24638Chlorosulfonic acidHCID 1358382213-Amino-5,6-dihydrobenzo[f]quinazolin-1(2H)-one

Product 1

HCID 135838097HCID 135838097, compound

Procedure

Chlorosulfonic acid(25 ml, Aldrich), cooled to 5° C. in ice, was stirred during its addition to 3-amino-1,2,5,6-tetrahydro-1-oxo-benzo[f]quinazoline (5 g, 0.025 mole)contained in a beaker immersed in an ice bath. The solution was removed from the ice bath, stirred for a further 20 min, then poured onto ice (1000 g). The solid product was removed by filtration, washed with water, and dried under high vacuum at room temperature. The sulfonyl chloride was used without further purification.

Workup

  1. customimmersed in an ice bath
  2. customThe solution was removed from the ice bath
  3. additionpoured onto ice (1000 g)
  4. customThe solid product was removed by filtration
  5. washwashed with water
  6. customdried under high vacuum at room temperature
  7. customThe sulfonyl chloride was used without further purification

Sources & evidence

ORD record
ord-020de7eea9164722b1ffa42d18d4221f
Source dataset
uspto-grants-2001_10
Patent number
US06306865B1

Reaction notes

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