反应详情

3-Amino-8-bromo-N,N,-diethyl-5,6-dihydrobenzo[f]quinazolin-1(2H)-one-9-sulfonamide (0.165 g,0.39 mmole) was suspended in pivalic anhydride (5 ml) (Aldrich) and heated under nitrogen until dissolved. The solution was heated under reflux for 10 minutes, cooled, and the pivalic anhydride removed in vacuo. The dried solid was dissolved in benzene (20 ml), pyridine (0.05 ml) added, and the solution heated to boiling under nitrogen. N-Bromosuccinimide (0.07 g, 0.47 mmole) was added, and the mixture refluxed for an additional 6 hours. The reaction mixture was cooled to room temperature, solvent removed in vacuo, and the solid residue crystallized from methanol. The pivalamide (0.105 g) was dissolved in methanol(2 ml), 1N NaOH(4 ml) added, and the solution heated to reflux under nitrogen for 1 hour. The cooled reaction mixture was neutralized with dilute acetic acid, the crystals collected by filtration and suspended in methanol. The collected crystals were dried in vacuo to give 3-amino-8-bromo-N,N-diethyl-1,2-dihydro-1-oxobenzo[f]quinazolin-9-sulfonamide (0.055 g, 33%). Mp>250° C. 1H NMR (DMSO-d6, 200 MHz) δ: 1.10 (t, J=7 Hz, 6H, ethyl CH3), 3.38 (q, J=7 Hz, 4H, ethyl CH2), 6.78 (br s, 2H, NH2), 7.47 (d, J=9 Hz, 1H, Ar), 8.09 (d, J=9 Hz, 1H, Ar), 8.40 (s, 1H, Ar), 10.30 (s, 1H, Ar), 11.32 (br s 1H, NH). Anal Calculated for C16H17BrN4O3S: C,45.19; H,4.03; Br,18.79; N,13.17; S,7.54. Found: C,45.10; H,4.03; Br,18.74; N,13.07; S,7.56.

1. temperatureheated under nitrogen
2. dissolutionuntil dissolved
3. temperatureThe solution was heated
4. temperatureunder reflux for 10 minutes
5. temperaturecooled
6. customthe pivalic anhydride removed in vacuo
7. dissolutionThe dried solid was dissolved in benzene (20 ml)
8. additionpyridine (0.05 ml) added
9. temperaturethe solution heated
10. temperaturethe mixture refluxed for an additional 6 hours
11. customsolvent removed in vacuo
12. customthe solid residue crystallized from methanol
13. dissolutionThe pivalamide (0.105 g) was dissolved in methanol(2 ml)
14. addition1N NaOH(4 ml) added
15. temperaturethe solution heated
16. temperatureto reflux under nitrogen for 1 hour
17. customThe cooled reaction mixture
18. filtrationthe crystals collected by filtration
19. customThe collected crystals were dried in vacuo