反应详情

To a chilled solution of 2-amino-4-fluorobenzoic acid (1.57 g, 10.1 mmol) in absolute ethanol (20 mL) was added neat thionyl chloride (4.4 mL, 60 mmol). The reaction mixture was refluxed for 4 days total, with addition of more SOCl2 (8 mL, 110 mmol), then concentrated, diluted with EtOAc, washed with 2N NaOH, dried and concentrated in vacuo to give ethyl 2-amino-4-fluorobenzoate (1.73 g, 94%).

1. temperatureThe reaction mixture was refluxed for 4 days total
2. concentrationconcentrated
3. additiondiluted with EtOAc
4. washwashed with 2N NaOH
5. customdried
6. concentrationconcentrated in vacuo