HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 3-(4-Phenethylpiperazin-1-yl)propanethiol dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Thiourea | HCID 2723790 | — |
| Reactant | 1-Phenethyl-4-(3-chloropropyl)piperazine dihydrochloride | HCID 20153179 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-(4-Phenethylpiperazin-1-yl)propanethiol dihydrochloride | HCID 13731124 | 81.6% |
Reaction Steps
The procedure described in Example 1(b) was followed, using 15.2 g of thiourea, 32.6 g of 1-phenethyl-4-(3-chloropropyl)piperazine dihydrochloride, 20.0 g of triethylamine and 250 ml of reagent ethanol. The hydrolysis was effected with 10.0 g of sodium hydroxide in 40 ml of water. Work-up, as described above, gave 26.4 g (79% of theory) of 3-(4-phenethylpiperazin-1-yl)propanethiol dihydrochloride as an off-white crystalline solid, M.p. 269°-272° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04722926 |
| Source dataset | uspto-grants-1988_02 |
| ORD ID | ord-a12cdbab8eb74afc9c6c800abef1a068 |
| Source note | uspto-grants-1988_02 |