Methanol → Maribavir

Participants

Reaction Steps

5,6-Dichloro-2-(isopropylamino)1-(2,3,5-tri-O-acetyl-beta-L-ribofuranosyl)-1H-benzimidazole (7.50 g, 14.93 mmol), sodium carbonate (1.72 g, 16.23 mmol), water (29 mL), methanol (100 mL) and ethanol (100 mL) were used according to general procedure III. The product was purified by silica gel chromatography using 55:45 dichloromethane/methanol to afford 4.72 g (84%) of a white foam. Analytical data were consistent with the assigned structure.

Provenance & Evidence