HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenylpropanolamine → (1S,2R)-2-amino-1-phenylpropan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenylpropanolamine | HCID 10297 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (1S,2R)-2-amino-1-phenylpropan-1-ol | HCID 26934 | — |
Reaction Steps
As shown in the scheme above, (1R, 2S)-(−)-norephedrine is reacted with an optionally substituted benzaldehyde by refluxing in ethanol, and reducing the product of that reaction with sodium borohydride at ambient temperature to produce the desired norephedrine derivative compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06307048B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-1d749c0eef934d3cbcb4053555977afb |
| Source note | uspto-grants-2001_10 |