Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phosgene → HCID 178481179, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phosgene | HCID 6371 | — |
| 반응물 | Piperidine | HCID 8082 | — |
| 반응물 | Ethyl orthoformate | HCID 31214 | — |
| 반응물 | 4-Fluoroanthranilic acid | HCID 2724967 | — |
| 반응물 | Methane, sulfinylbis-, ion(1-), sodium | HCID 10154010 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | HCID 178481179 | HCID 178481179 | — |
반응 단계
starting with 4-fluoroanthranilic acid comprising cyclization with phosgene to create an intermediate -A, followed by methylation to create an intermediate -B, then by reaction with dimsyl sodium to create an intermediate -C, then by reaction with triethyl orthoformate in the presence of piperdine and acetic acid to give flosequinan. The overall yield of the disclosed process is greater than about 16%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06307050B1 |
| 출처 데이터셋 | uspto-grants-2001_10 |
| ORD ID | ord-9604846a8b2848ef94d287caf71cf1df |
| 출처 메모 | uspto-grants-2001_10 |