HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 381684Generated: October 31, 2026
Sodium Bicarbonate → HCID 85071360, compound
https://huagongshe.com/reaction/381684
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 4-fluoro-N-(piperidin-4-yl)benzamide | HCID 4778226 | — |
| Reactant | HCID 57299650 | HCID 57299650 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 85071360 | HCID 85071360 | 65.8% |
Reaction Steps
A mixture of 520 mg 6-(3-chloromethyl-phenylmethoxy)-2-cinnamylidenecoumaran-3-one (preparation 6), 150 mg sodium hydrogencarbonate, 330 mg 4-(4-fluorobenzamido)piperidine and 15 ml dimethylformamide is warmed to 60° C. for 3 hours, then evaporated, mixed with water and extracted with ethyl acetate. After evaporation of the extract, the residue is purified by silica gel chromatography (eluent ethyl acetate) to give 500 mg (65%) of the desired compound, m.p. 126-128° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06307051B1 |
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| Source dataset | uspto-grants-2001_10 |
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| ORD ID | ord-1e629a4246094ccd8e2d92642873b090 |
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| Source note | uspto-grants-2001_10 |
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