HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylene Glycol → Simvastatin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethylene Glycol | HCID 174 | — |
| Reactant | 1,3-Propanediol | HCID 10442 | — |
| Reactant | Neopentyl glycol | HCID 31344 | — |
| Reactant | HCID 178445512 | HCID 178445512 | — |
| Solvent | Water | HCID 962 | — |
| Product | Simvastatin | HCID 54454 | — |
Reaction Steps
Simvastatin boronate (III) is heated in the presence of a suitable diol solvent selected from ethylene glycol, 1,3-propanediol, or neopentyl glycol, under thermal conditions. The product is isolated by concentration of the reaction mixture, dilution with water, and extraction with an organic solvent. The organic solvent is concentrated to a minimum volume and simvastatin is isolated by the addition of a cosolvent and filtration.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06307066B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-668282ea8a434ec39afca7f89dc75d3b |
| Source note | uspto-grants-2001_10 |