HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Simvastatin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | HCID 178445512 | HCID 178445512 | — |
| Solvent | Water | HCID 962 | — |
| Product | Simvastatin | HCID 54454 | — |
Reaction Steps
Alternatively, III may be agitated in a mixture of water and an organic solvent, preferably methanol, under high dilution conditions to produce simvastatin in its acid form. Simvastatin acid may be isolated by extraction or crystallization and relactonized to produce simvastatin.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06307066B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-fd52504a35e746cd8b8005092cc39f97 |
| Source note | uspto-grants-2001_10 |