HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine hydrochloride → 4-Chloro-8-methoxy-2-(2-trifluoromethylphenyl)-quinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine hydrochloride | HCID 11130 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 8-methoxy-2-(2-trifluoromethyl-phenyl)-3H-quinazolin-4-one | HCID 135850831 | — |
| Product | 4-Chloro-8-methoxy-2-(2-trifluoromethylphenyl)-quinazoline | HCID 21939237 | 89% |
Reaction Steps
Prepared from 8-methoxy-2-(2-trifluoromethyl-phenyl)-3H-quinazolin-4-one (1.0 g, 3.12 mmol), triethylamine hydrochloride (472 mg, 3.43 mmol), and POCl3. Purification by flash chromatography afforded a white solid (89% yield). HPLC-Method A, Rt 4.10 min, (98%), MS (m/z) 258.08 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08524720B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-5c39562b757e41e2b43bc8e67bd374ae |
| Source note | uspto-grants-2013_09 |