Isopropyl 4,4,4-Trifluoroacetoacetate → Isopropyl 4,4,4-trifluoro-3-hydroxybutyrate

Participants

Reaction Conditions

Reaction Steps

Isopropyl 4,4,4-trifluoroacetoacetate (50 g), under a blanket of nitrogen gas, is heated to 40° C. and treated with platinum (0.1 g of 5% Pt/C, 0.01% load) and triethylamine (0.2 g, 0.4 % load). Hydrogen is charged to a pressure of 5 bars, and the mixture agitated at 40° C. for 6h. After filtration to remove the catalyst, 48.5 g (96% yield) of isopropyl 4,4,4-trifluoro-3-hydroxybutyrate is obtained.

Provenance & Evidence